The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

@article{Wetering2002TheBC,
  title={The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.},
  author={M L J M van de Wetering and Elena Sancho and C. L. Verweij and Wim B. M. de Lau and Irma M Oving and Adam F L Hurlstone and Karin van der Horn and Eduard Batlle and Damien Coudreuse and Anna Pavlina Haramis and Menno Tjon-Pon-Fong and Petra Moerer and Maaike van den Born and Gwen A J Soete and Steven Pals and Martin Eilers and Ren{\'e} H Medema and Hans Clevers},
  journal={Cell},
  year={2002},
  volume={111 2},
  pages={241-50}
}
The transactivation of TCF target genes induced by Wnt pathway mutations constitutes the primary transforming event in colorectal cancer (CRC). We show that disruption of beta-catenin/TCF-4 activity in CRC cells induces a rapid G1 arrest and blocks a genetic program that is physiologically active in the proliferative compartment of colon crypts. Coincidently, an intestinal differentiation program is induced. The TCF-4 target gene c-MYC plays a central role in this switch by direct repression of… CONTINUE READING
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