The beta-adrenoceptor-adenylate cyclase complex

  title={The beta-adrenoceptor-adenylate cyclase complex},
  author={Ad P. Ijzerman and Henk Timmerman},
  journal={Pharmaceutisch Weekblad},
Developments in the receptor concept have greatly influenced our current knowledge of the beta-adrenoceptor. The triad of pharmacology, organic chemistry and studies in structure-activity relationships is discussed along historical lines, as it has been and still is an impetus for progress in the biochemistry of ligand-receptor interactions. With respect to the beta-adrenoceptor complex these advances which have led to a model in which three protein structures are functionally interacting… CONTINUE READING