The beta-2 adrenergic receptor and its agonists.

  title={The beta-2 adrenergic receptor and its agonists.},
  author={William K. Dolen},
  journal={Allergy proceedings : the official journal of regional and state allergy societies},
  volume={15 6},
  • William K. Dolen
  • Published 1994 in
    Allergy proceedings : the official journal of…
The beta 2 adrenoceptor has been cloned and sequenced, and details of how agonist stimulation ultimately results in clinically evident effects are now known. Receptor desensitization by agonist is an almost universal process that can be prevented and reversed by corticosteroids. Although immunologic mechanisms appear to prevail in asthma, beta 2 receptor dysfunction may be important in some circumstances. Many receptor agonists are available for asthma therapy, including a new generation of… CONTINUE READING