The bestrophin family of anion channels: identification of prokaryotic homologues.

@article{Hagen2005TheBF,
  title={The bestrophin family of anion channels: identification of prokaryotic homologues.},
  author={Andrew R Hagen and Ravi D. Barabote and Milton H. Saier},
  journal={Molecular membrane biology},
  year={2005},
  volume={22 4},
  pages={291-302}
}
The human disease protein, Bestrophin-1, associated with vitelliform macular dystrophy, has recently been shown to be an integral membrane anion channel-forming protein. In this study we have recovered all bestrophin homologues from the NCBI database and analyzed their sequences using bioinformatic approaches. Eukaryotic homologues were found in animals and fungi but not in plants or protozoans, and prokaryotic homologues distantly related to the eukaryotic proteins, were identified in certain… CONTINUE READING