The best of times, the worst of times for psychiatric disease

@article{Karayiorgou2012TheBO,
  title={The best of times, the worst of times for psychiatric disease},
  author={Maria Karayiorgou and Jonathan Flint and Joseph A Gogos and Robert C Malenka},
  journal={Nature Neuroscience},
  year={2012},
  volume={15},
  pages={811-812}
}
with case/control samples, from hidden ethnic stratification effects and immense neutral background variation. The path taken to arrive at that point will likely vary depending on the disease being studied: in schizophrenia and autism there is clear evidence that a direct search for rare variants would be fruitful, either for structural variants or rare deleterious coding mutations. The genetic architecture of other psychiatric disorders, such as major depression and anxiety disorders, may be… CONTINUE READING
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14 Allen Institute for Brain Science 15 Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Howard Hughes Medical Institute

17 Neurogenetics Program