The benzodiazepines: Anxiolytic and withdrawal effects

@article{Little1991TheBA,
  title={The benzodiazepines: Anxiolytic and withdrawal effects},
  author={H. Little},
  journal={Neuropeptides},
  year={1991},
  volume={19},
  pages={11-14}
}
  • H. Little
  • Published 1991
  • Biology, Medicine
  • Neuropeptides
Benzodiazepine withdrawal, spontaneous or precipitated by the receptor antagonist, flumazenil, produces anxiety that can be measured in animal models. Benzodiazepine inverse agonists also cause anxiety. Their convulsive effects increase after chronic agonist treatment, but they become anxiolytic. Decreases in GABAA receptor sensitivity occur after chronic benzodiazepine treatment. Flumazenil, given 24h prior to the measurements, prevented both the sensitivity changes and benzodiazepine… Expand
View on Elsevier
doi.org
29 Citations
Background Citations
6

29 Citations

Citation Type

Citation Type

Flumazenil blockade of anxiety following ethanol withdrawal in rats
  • 85
The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress.
  • 33
GABA-A receptor modulators alter emotionality and hippocampal theta rhythm in an animal model of long-lasting anxiety
  • 12
Effectiveness of flumazenil (RO 15-1788) in the treatment of benzodiazepine withdrawal
  • 14
Central and peripheral benzodiazepine receptors in rat brain and platelets: effects of treatment with diazepam and clobazam
  • 2
Opioid and benzodiazepine tolerance and dependence: application of theory to critical care practice.
  • 42
Peripheral benzodiazepine receptors in platelets of epileptic patients.
  • 9
Progesterone withdrawal effects in the open field test can be predicted by elevated plus maze performance
  • 31
Benzodiazepine/cholecystokinin interactions at functional CCK receptors in rat brain
  • 4
Withdrawal Symptoms Among Chronic Users of Oral Benzodiazepines for Anxiety Disorders
  • PDF
...
1
2
3
...

References

SHOWING 1-10 OF 14 REFERENCES
Reversal of increased anxiety during benzodiazepine withdrawal: Evidence for an anxiogenic endogenous ligand for the benzodiazepine receptor
  • 58
Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity
  • 277
Chronic benzodiazepine treatment increases the effects of the inverse agonist FG7142
  • 35
Anxiogenic effects in benzodiazepine withdrawal are linked to the development of tolerance
  • 63
The use of flumazenil in prevention of Diazepam dependence in the rat
  • 17
Flumazenil but not nitrendipine reverses the increased anxiety during ethanol withdrawal in the rat
  • 70
Anxiogenic aspects of diazepam withdrawal can be detected in animals.
  • 52
Unusual interactions of benzodiazepine receptor antagonists
  • 285
The effects of benzodiazepine agonists, inverse agonists and Ro 15–1788 on the responses of the superior cervical ganglion to GABA in vitro
  • H. Little
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1984
  • 28
Are changes in neuronal calcium channels involved in ethanol tolerance?
  • S. Dolin, H. Little
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1989
  • 99
...
1
2
...