The benzodiazepines: Anxiolytic and withdrawal effects

@article{Little1991TheBA,
  title={The benzodiazepines: Anxiolytic and withdrawal effects},
  author={H. Little},
  journal={Neuropeptides},
  year={1991},
  volume={19},
  pages={11-14}
}
  • H. Little
  • Published 1991
  • Biology, Medicine
  • Neuropeptides
Benzodiazepine withdrawal, spontaneous or precipitated by the receptor antagonist, flumazenil, produces anxiety that can be measured in animal models. Benzodiazepine inverse agonists also cause anxiety. Their convulsive effects increase after chronic agonist treatment, but they become anxiolytic. Decreases in GABAA receptor sensitivity occur after chronic benzodiazepine treatment. Flumazenil, given 24h prior to the measurements, prevented both the sensitivity changes and benzodiazepine… Expand
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