The benzodiazepine binding site of GABAA receptors as a target for the development of novel anxiolytics

  title={The benzodiazepine binding site of GABAA receptors as a target for the development of novel anxiolytics},
  author={J. Atack},
  journal={Expert Opinion on Investigational Drugs},
  pages={601 - 618}
  • J. Atack
  • Published 2005
  • Medicine
  • Expert Opinion on Investigational Drugs
  • Non-selective benzodiazepine (BZ) binding-site full agonists, exemplified by diazepam, act by enhancing the inhibitory effects of GABA at GABAA receptors containing either an α1, -2, -3 or -5 subunit. However, despite their proven clinical anxiolytic efficacy, such compounds possess a relatively narrow window between doses that produce anxiolysis and those that cause sedation, and are also associated with physical dependence and a potential for abuse. In the late 1980s and early 1990s a number… CONTINUE READING
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