The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial

@inproceedings{Sandercock2012TheBA,
  title={The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial},
  author={Peter Ag Sandercock and Joanna M. Wardlaw and Richard I Lindley and Martin Dennis and Geoff Cohen and Gordon Murray and Karen Innes and Graham S. Venables and Anna Czlonkowska and A Kobayashi and Stefano Ricci and Veronica Murray and Eivind Berge and Karsten Bruins Slot and Graeme J. Hankey and Manuel Gomes Correia and Andre Philippe Peeters and Karl Matz and Phillippe Lyrer and Gordon J Gubitz and Steve Phillips and Antonio Ara{\'u}z},
  booktitle={The Lancet},
  year={2012}
}
BACKGROUND Thrombolysis is of net benefit in patients with acute ischaemic stroke, who are younger than 80 years of age and are treated within 4·5 h of onset. The third International Stroke Trial (IST-3) sought to determine whether a wider range of patients might benefit up to 6 h from stroke onset. METHODS In this international, multicentre, randomised, open-treatment trial, patients were allocated to 0·9 mg/kg intravenous recombinant tissue plasminogen activator (rt-PA) or to control. The… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 97 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 334 extracted citations

Timing of tissue plasminogen activator for acute ischemic stroke: outcomes-based recommendations for practice.

The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses • 2014
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Trial - 3 ( IST - 3 )

M WardlawJ, V Murray, E Berge
2012

: a proposal

PD Lyden
2010

Similar Papers

Loading similar papers…