The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3.

@article{Lima2007TheBE,
  title={The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3.},
  author={E G Lima and Liming Bian and Kenneth W. Ng and Robert L Mauck and Benjamin A Byers and Rocky S Tuan and Gerard A. Ateshian and Clark Tung-Hui Hung},
  journal={Osteoarthritis and cartilage},
  year={2007},
  volume={15 9},
  pages={1025-33}
}
OBJECTIVE To determine whether the functional properties of tissue-engineered constructs cultured in a chemically-defined medium supplemented briefly with TGF-beta3 can be enhanced with the application of dynamic deformational loading. METHODS Primary immature bovine cells (2-3 months old) were encapsulated in agarose hydrogel (2%, 30 x 10(6)cells/ml) and cultured in chemically-defined medium supplemented for the first 2 weeks with transforming growth factor beta 3 (TGF-beta3) (10 microg/ml… CONTINUE READING

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Temporal exposure of TGF-beta3 under serum-free conditions enhances biomechanical and biochemical maturation of tissue-engineered cartilage

  • B Byers, R Mauck, I Chiang, R. Tuan
  • ORS, Volume 31. Chicago,
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