The behavioural effects of intrahypothalamic multistage versus single injections of 6-hydroxydopamine

@article{Willis1982TheBE,
  title={The behavioural effects of intrahypothalamic multistage versus single injections of 6-hydroxydopamine},
  author={Gregory Lynn Willis and Graeme C. Smith},
  journal={Brain Research},
  year={1982},
  volume={245},
  pages={345-352}
}
Sensitivity of dopamine receptors in the lateral hypothalamus is altered in 6-hydroxydopamine treated rats.
TLDR
It is suggested that prolonged exposure of hypothalamic DA receptors alters their sensitivity to subsequent doses of DA and that amine released from areas of accumulation may be blocked by haloperidol to enhance behavioral recovery from DA depleting lesions.
Dopamine Neurone Degeneration-Like Deficits Produced by Intrahypothalamic Dopamine Injections
TLDR
Results add further support to the hypothesis that amines which accumulate in degenerating neurones may be neuroactive and may participate in the production of behavioural deficits attributed previously to the loss of dopamine neurotransmission.
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Central actions of 6-hydroxydopamine and other phenylethylamine derivatives on body temperature in the rat.
TLDR
The hypothermic response to α-methylnorepinephrine was markedly enhanced by "central sympathectomy" suggesting that at least a part of its activity was related to a "direct" action of this amine on central receptors which was enhanced by the neuronal destruction caused by 6-hydroxydopamine.
Recovery of Feeding and Drinking by Rats after Intraventricular 6-Hydroxydopamine or Lateral Hypothalamic Lesions
TLDR
Both the loss and recovery of feeding and drinking behaviors may involve central catecholamine-containing neurons in rats given intraventricular injections of 6-hydroxydopamine.
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