The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation.

@article{Fndrich2002TheBO,
  title={The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation.},
  author={Marcus F{\"a}ndrich and Christopher M. Dobson},
  journal={The EMBO journal},
  year={2002},
  volume={21 21},
  pages={5682-90}
}
Amyloid fibrils and prions are proteinaceous aggregates that are based on a unique form of polypeptide configuration, termed cross-beta structure. Using a group of chemically distinct polyamino acids, we show here that the existence of such a structure does not require the presence of specific side chain interactions or sequence patterns. These observations firmly establish that amyloid formation and protein folding represent two fundamentally different ways of organizing polypeptides into… CONTINUE READING