The behavioral genetics ofCaenorhabditis elegans

  title={The behavioral genetics ofCaenorhabditis elegans},
  author={Eve Wolinsky and Jeffrey C. Way},
  journal={Behavior Genetics},
Caenorhabditis elegans, a small free-living soil nematode, is an ideal organism for the genetic dissection of simple behaviors. Over 150 genes required for normal behavior have been identified. We review here the neural and genetic pathways underlying four of the best-studiedC. elegans behaviors: locomotion, response to gentle touch, egg-laying, and chemotaxis. Mutations affecting these behaviors have identified genes which specify neuronal cell lineage, neuronal cell fate, and the formation of… 
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Thirty-five genes define a pathway for the development of the hermaphrodite-specific neurons (HSNs) in Caenorhabditis elegans, revealing that the genes specifying HSN development also function in the developmentof other cell types.
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Egg-laying defective mutants of the nematode Caenorhabditis elegans.
Two of the HSN-defective mutants, egl-1 and her-1(n695) animals exhibit multiple morphological pleiotropies, displaying partial transformation of the sexual phenotype of many cells and tissues and may define new components of the neural circuitry that control egg laying.
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A small group of genes in the nematode Caenorhabditis elegans that, when mutated, confer resistance to the potent anthelmintic levamisole are characterized and it is proposed that these mutants represent a favorable system for understanding how a smallgroup of related genes function in a simple animal.
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