The behavioral functions of the cholinergic basalforebrain : lessons from 192 IgG-SAPORIN

@article{Wrenn1998TheBF,
  title={The behavioral functions of the cholinergic basalforebrain : lessons from 192 IgG-SAPORIN},
  author={Craige C. Wrenn and Ronald G. Wiley},
  journal={International Journal of Developmental Neuroscience},
  year={1998},
  volume={16},
  pages={595-602}
}
Until recently our understanding of the functional neuroanatomy of the cholinergic basal forebrain (CBF) has been hindered by the lack of a lesioning technique that is truly selective. The development of the immunotoxin 192 IgG-saporin (192-sap) has greatly improved our ability to create specific lesions of the CBF. Rats with such lesions have been studied in a wide variety of behavioral paradigms of learning, memory, and attention. Complete or near-complete destruction of the CBF results in… CONTINUE READING

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