The behavioral effects of a mixed efficacy antinociceptive peptide, VRP26, following chronic administration in mice

@article{Anand2016TheBE,
  title={The behavioral effects of a mixed efficacy antinociceptive peptide, VRP26, following chronic administration in mice},
  author={Jessica P. Anand and Brett T. Boyer and Henry I. Mosberg and Emily M Jutkiewicz},
  journal={Psychopharmacology},
  year={2016},
  volume={233},
  pages={2479-2487}
}
VRP26 displays mu opioid receptor agonist and delta opioid receptor antagonist activity in vitro, a pharmacological profile purported to produce reduced tolerance, dependence, and rewarding effects. We hypothesized that VRP26 would display reduced adverse effects after chronic administration as compared with the traditional opioid analgesic fentanyl. The aim of this study is to explore the development of tolerance, dependence, and conditioned place preference of VRP26 as compared with the… CONTINUE READING
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