The behavioral effects of NMDA antagonists in serotonin depleted rats.

@article{Panik1997TheBE,
  title={The behavioral effects of NMDA antagonists in serotonin depleted rats.},
  author={Adam Płaźnik and Maria Jessa and Michael Nazar},
  journal={Pharmacology, biochemistry, and behavior},
  year={1997},
  volume={58 1},
  pages={159-66}
}
The influence of serotonin (5-HT) depletion (5,7-dihydroxytryptamine, 5,7-DHT, 250.0 micrograms, ICV), on behavioral effects of non-competitive (MK-801) and competitive (CGP 37849) NMDA antagonists, was examined in rats. 5,7-DHT induced very potent and long lasting decrease in the 5-HT concentration in the brainstem and limbic forebrain. One week after 5,7… CONTINUE READING