The behavior of Gliclazide in solution and in the solid state: a case of organic compound presenting a solid-solution structure.


The structure of the hypoglycemic agent Gliclazide has been studied by (1)H, (13)C, and (15)N NMR in solution (CDCl(3) and DMSO-d(6)) and in the solid state. In the solid state, the compound crystallizes as an EZ isomer without dynamic properties. In CDCl(3) solution, the structure is still EZ but with a slow nitrogen inversion about the pyrrolidine… (More)
DOI: 10.1002/mrc.2414


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