The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype.

@article{BootHandford1998TheBK,
  title={The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype.},
  author={Ray P. Boot-Handford and Theologos M. Michaelidis and M. Chantal Hillarby and Alberto Zambelli and Jerod Denton and Judith A Hoyland and Anthony John Freemont and Michael E. Grant and Gillian A. Wallis},
  journal={International journal of experimental pathology},
  year={1998},
  volume={79 5},
  pages={329-35}
}
Histological examination of long bones from 1-day-old bcl-2 knockout and age-matched control mice revealed no obvious differences in length of bone, growth plate architecture or stage of endochondral ossification. In 35-day-old bcl-2 knockout mice that are growth retarded or 'dwarfed'. the proliferative zone of the growth plate appeared slightly thinner and… CONTINUE READING