The bcl-2 gene is rearranged in many diffuse B-cell lymphomas.

  title={The bcl-2 gene is rearranged in many diffuse B-cell lymphomas.},
  author={Alan C. Aisenberg and Barry M. Wilkes and Joseph O Jacobson},
  volume={71 4},
Southern blotting was used to detect rearrangement of the bcl-2 gene in 104 cases of non-Hodgkin's lymphoma subclassified by the Working Formulation, 24 cases of B cell chronic lymphocytic leukemia (B-CLL) and 14 cases of T cell malignancy. Earlier workers reported rearrangement of this gene (located on chromosome 18) in a major fraction of follicular lymphomas, lymphomas in which a 14;18 chromosome translocation is frequently observed. In the present study, bcl-2 was rearranged in 30% (11 of… CONTINUE READING


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