The bcl-2 gene family.

@article{Craig1995TheBG,
  title={The bcl-2 gene family.},
  author={Ruth W. Craig},
  journal={Seminars in cancer biology},
  year={1995},
  volume={6 1},
  pages={
          35-43
        }
}
Viability is a fundamental determinant of all cellular functions, and regulation of cell viability is important in shaping tissue differentiation and organism development. The genes in the bcl-2 family can profoundly influence cell viability. In addition to bcl-2, cellular genes in this family include bcl-x, bax, mcl-1, and A1 (from vertebrates), as well as ced9 (from Caenorhabditis elegans). Different members of the family exhibit a spectrum of activity, ranging from survival-enhancement of… CONTINUE READING
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