The bcl-2 and p53 oncoproteins can be modulated by bryostatin 1 and dolastatins in human diffuse large cell lymphoma.

@article{Maki1995TheBA,
  title={The bcl-2 and p53 oncoproteins can be modulated by bryostatin 1 and dolastatins in human diffuse large cell lymphoma.},
  author={A Maki and Hari H. Diwakaran and Bruce G. Redman and S al-Asfar and George R. Pettit and Ramzi M. Mohammad and Ayad Al-Katib},
  journal={Anti-cancer drugs},
  year={1995},
  volume={6 3},
  pages={
          392-7
        }
}
The effects of dolastatin 10 (Dol10) and dolastatin 15 (Dol15) alone, and after treatment with bryostatin 1 (Bryo1), on human diffuse large cell lymphoma cell line (WSU-DLCL2) were studied. At a concentration of 1.0 ng/ml Dol10 and Dol15 showed significant growth inhibition (p < 0.05). This inhibition was intensified when the cells were pretreated for 24 h with 200 nM Bryo1. Bryo1, Dol10 and Dol15 induced apoptosis which was seen on morphological examination, by flow cytometry and DNA… Expand
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