The basolateral domain of the hepatocyte plasma membrane bears receptors for the circumsporozoite protein of Plasmodium falciparum sporozoites.

@article{Cerami1992TheBD,
  title={The basolateral domain of the hepatocyte plasma membrane bears receptors for the circumsporozoite protein of Plasmodium falciparum sporozoites.},
  author={C Cerami and Ute Frevert and Photini Sinnis and B{\'e}la J. Tak{\'a}cs and Pedro Clavijo and Maria Jos{\'e} Santos and Victor Nussenzweig},
  journal={Cell},
  year={1992},
  volume={70 6},
  pages={1021-33}
}
Minutes after injection into the circulation, malaria sporozoites enter hepatocytes. The speed and specificity of the invasion process suggest that it is receptor mediated. We show here that recombinant Plasmodium falciparum circumsporozoite protein (CS) binds specifically to regions of the plasma membrane of hepatocytes exposed to circulating blood in the Disse space. No binding has been detected in other organs, or even in other regions of the hepatocyte membrane. The interaction of CS with… CONTINUE READING