The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.

@article{Long2000TheBF,
  title={The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.},
  author={Stephen Barstow Long and Patrick J. Casey and Lorena S. Beese},
  journal={Structure},
  year={2000},
  volume={8 2},
  pages={209-22}
}
BACKGROUND The protein farnesyltransferase (FTase) catalyzes addition of the hydrophobic farnesyl isoprenoid to a cysteine residue fourth from the C terminus of several protein acceptors that are essential for cellular signal transduction such as Ras and Rho. This addition is necessary for the biological function of the modified proteins. The majority of… CONTINUE READING