The basic structural lesion of persistent neonatal hypoglycaemia with hyperinsulinism: deficiency of pancreatic D cells or hyperactivity of B cells?

@article{Rahier1984TheBS,
  title={The basic structural lesion of persistent neonatal hypoglycaemia with hyperinsulinism: deficiency of pancreatic D cells or hyperactivity of B cells?},
  author={Jacques Rahier and K. F{\"a}lt and Horst M{\"u}ntefering and Klaus -Peter Becker and Willy Gepts and Sture E. Falkmer},
  journal={Diabetologia},
  year={1984},
  volume={26},
  pages={282-289}
}
Pancreatic tissue obtained at subtotal pancreatectomy from 15 infants with persistent hypoglycaemia with hyperinsulinism, and autopsy specimens from 23 age-matched normoglycaemic controls, were studied with morphometric methods after immunocytochemical staining of the four main islet cell types (A, B, D and pancreatic polypeptide cells). In three cases, a focal lesion was detected by gross examination. Macroscopic or microscopic examination did not distinguish the 12 other cases from controls… CONTINUE READING

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