The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development

@article{Gascoyne2009TheBL,
  title={The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development},
  author={Duncan M. Gascoyne and Elaine T. Long and Henrique Veiga-Fernandes and Jasper de Boer and Owen Williams and Benedict Seddon and Mark Coles and Dimitris Kioussis and Hugh J M Brady},
  journal={Nature Immunology},
  year={2009},
  volume={10},
  pages={1118-1124}
}
Natural killer (NK) cells are a subset of lymphocytes crucial for innate immunity and modification of adaptive immune responses. In contrast to commitment to the T cell or B cell lineage, little is known about NK cell lineage commitment. Here we show that the basic leucine zipper (bZIP) transcription factor E4BP4 (also called NFIL3) is essential for generation of the NK cell lineage. E4BP4-deficient mice (Nfil3−/–; called 'E4bp4−/–' here) had B cells, T cells and NKT cells but specifically lack… CONTINUE READING
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  • C Hough
  • Blood 105,
  • 2005
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