The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of myoD.

@article{Lemercier1998TheBH,
  title={The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of myoD.},
  author={Claudie Lemercier and R Q To and Rosa A Carrasco and Stephen F Konieczny},
  journal={The EMBO journal},
  year={1998},
  volume={17 5},
  pages={1412-22}
}
A good model system to examine aspects of positive and negative transcriptional regulation is the muscle-specific regulatory factor, MyoD, which is a basic helix-loop-helix (bHLH) transcription factor. Although MyoD has the ability to induce skeletal muscle terminal differentiation in a variety of non-muscle cell types, MyoD activity itself is highly regulated through protein-protein interactions involving several different co-factors. Here we describe the characterization of a novel bHLH… CONTINUE READING
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