The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain.

@article{Sakamoto2003TheBH,
  title={The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain.},
  author={Masami Sakamoto and Hiromi Hirata and Toshiyuki Ohtsuka and Yasumasa Bessho and Ryoichiro Kageyama},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 45},
  pages={44808-15}
}
Neural precursor cells proliferate in the ventricular zone while giving rise to neurons of deep layers first, then those of the superficial layers, and lastly, glial cells in the brain. Thus, it is essential to maintain neural precursor cells until late stages of neural development for generation of a wide variety of cell types. Here, we found that the Hes-related basic helix-loop-helix (bHLH) genes Hesr1/Hey1 and Hesr2/Hey2 are expressed in the ventricular zone, which contains neural precursor… CONTINUE READING

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