• Corpus ID: 90392289

The balancing effect between MAPK and NFκB pathways for the transcriptional regulation of Toll-like receptors

@inproceedings{Hong2016TheBE,
  title={The balancing effect between MAPK and NF$\kappa$B pathways for the transcriptional regulation of Toll-like receptors},
  author={Xinyang Hong},
  year={2016}
}
  • X. Hong
  • Published 2016
  • Biology, Environmental Science
Toll-like receptors (TLR) are a family of pattern recognition receptors crucial for pathogen pattern recognition. Upon activation, TLRs induce innate immune responses such as cytokine production. However irregular TLR activities can provide fatal, hence fine tuning of the TLR induced responses are necessary. The TLR mediated immune responses are controlled by the positive/negative regulation of TLR signalling pathways, relocation of TLR proteins and modulation of TLR transcription. Systematic… 

References

SHOWING 1-10 OF 276 REFERENCES
Signaling Crosstalk during Sequential TLR4 and TLR9 Activation Amplifies the Inflammatory Response of Mouse Macrophages1
TLDR
It is shown that rather than inducing tolerance, LPS pretreatment primed the inflammatory response of mouse bone marrow-derived macrophages to the TLR9 ligand, CpG DNA, which highlights the importance of signaling crosstalk between TLRs, as well as betweenTLRs and c-Fms, in regulating the inflammatory reaction to pathogens.
STAT1 plays a role in TLR signal transduction and inflammatory responses
TLDR
It is reported here that STAT1 rapidly undergoes phosphorylation following TLR4 challenge with lipopolysaccharide (LPS) in a model of LPS hypersensitivity in vivo and that the direct activation of STAT1 by TLR signaling suggests a crucial role for STAT1 in TLR‐induced inflammation.
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
TLDR
The results show that TIRAP has a crucial role in the MyD88-dependent signalling pathway shared by TLR2 and TLR4, and is not specific to TLR3, TLR7 or TLR9 signalling, which is in contrast to previous suggestions.
Transcriptional Regulation of the Novel Toll-like Receptor Tlr13*
TLDR
The mechanism of Tlr13 gene regulation is revealed, thereby providing insight into the function of TLR13 in the immune response to pathogen, and three cis-acting elements that interacted with the Ets2, Sp1, and PU.1 transcription factors may cooperate.
Role of adapters in Toll-like receptor signalling.
TLDR
Evidence is now accumulating showing that differential utilization of these adaptors may activate overlapping as well as distinct signalling pathways, and ultimately give rise to distinct biological effects exerted by individual TLR family members.
A Role for the Adaptor Proteins TRAM and TRIF in Toll-like Receptor 2 Signaling*
TLDR
The results show a novel function of TRAM and TRIF inTLR2-mediated signal transduction, and the findings broaden the understanding of how Toll/interleukin-1 receptor adaptor proteins may participate in signaling downstream from TLR2.
Cooperation of TLR12 and TLR11 in the IRF8-Dependent IL-12 Response to Toxoplasma gondii Profilin
TLDR
It is established that, in addition to TLR11, TLR12 recognizes the profilin protein of the protozoan parasite Toxoplasma gondii and regulates IL-12 production by DCs in response to the parasite.
Reprogramming of Murine Macrophages through TLR2 Confers Viral Resistance via TRAF3-Mediated, Enhanced Interferon Production
TLDR
It is reported that prior ligation of TLR2, an event previously shown to induce “homo” or “hetero” tolerance, strongly “primes” macrophages for increased Type I IFN production in response to subsequent TLR/RLR signaling.
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
TLDR
It is demonstrated that cells lacking TRAF3, a member of the TNF receptor-associated factor family, are defective in type I IFN responses activated by several different TLRs, suggesting that TRAF 3 serves as a critical link between TLR adaptors and downstream regulatory kinases important for IRF activation.
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