The balance of pro-inflammatory and trophic factors in multiple sclerosis patients: effects of acute relapse and immunomodulatory treatment.

@article{Lindquist2011TheBO,
  title={The balance of pro-inflammatory and trophic factors in multiple sclerosis patients: effects of acute relapse and immunomodulatory treatment.},
  author={Sabine Lindquist and Sarah Hassinger and Jonathan A. Lindquist and Michael Sailer},
  journal={Multiple sclerosis},
  year={2011},
  volume={17 7},
  pages={851-66}
}
BACKGROUND In multiple sclerosis inflammation is primarily injurious to the central nervous system, but its therapeutic suppression might inhibit repair-promoting factors. OBJECTIVES We aimed at better describing the complexity of biological effects during an acute relapse and analysed the effects of intervention with high-dose i.v. glucocorticoids and immunomodulatory treatment with interferon-beta (IFNβ). METHODS We studied the intracellular expression levels of the pro-inflammatory… CONTINUE READING
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