The balance of Polo-like kinase 1 in tumorigenesis

@article{Lu2009TheBO,
  title={The balance of Polo-like kinase 1 in tumorigenesis},
  author={Lin-Yu Lu and Xiaochun Yu},
  journal={Cell Division},
  year={2009},
  volume={4},
  pages={4 - 4}
}
Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key role to ensure the normal mitosis. Interestingly, overexpression of Plk1 is associated with tumor development and could serve as a prognostic marker for many cancers. Due to Plk1 overexpression, several Plk1 inhibitors have been developed and tested for the cancer treatment. However, in a… CONTINUE READING

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