The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells

@article{Donati2011TheBB,
  title={The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells},
  author={Giulio Donati and Sara Bertoni and Elisa Brighenti and Manuela Vici and Davide Trer{\'e} and Sini{\vs}a Volarevi{\'c} and Lorenzo Montanaro and Massimo Derenzini},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={3274-3288}
}
Data on the relationship between ribosome biogenesis and p53 function indicate that the tumour suppressor can be activated by either nucleolar disruption or ribosomal protein defects. However, there is increasing evidence that the induction of p53 does not always require these severe cellular changes, and data are still lacking on a possible role of ribosome biogenesis in the downregulation of p53. Here, we studied the effect of the up- and downregulation of the rRNA transcription rate on p53… CONTINUE READING

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