The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioning.

@article{Gonzlez2002TheBB,
  title={The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioning.},
  author={Mercedes Gonz{\'a}lez and Sergio A Quezada and Bruce R Blazar and Angela Panoskaltsis-Mortari and Alexander Y Rudensky and Randolph J. Noelle},
  journal={Journal of immunology},
  year={2002},
  volume={169 10},
  pages={5581-9}
}
Graft-vs-host disease (GVHD) remains the most life-threatening complication following the transfer of allogeneic bone marrow into immunocompromised hosts. Transferred alloreactive T cells respond in a complex manner. While massive T cell expansion is observed upon entry into an allogeneic environment, anergy, apoptosis, and repertoire selection are also observed. The study presented here shows that alloreactive T cell expansion and differentiation vs anergy and suppression are dramatically… CONTINUE READING

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