The balance between Cu,Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress.

@article{Amstad1991TheBB,
  title={The balance between Cu,Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress.},
  author={Paul A. Amstad and Alexander V. Peskin and Girish Shah and M. E. Mirault and R{\'e}my Moret and Ir{\`e}ne Zbinden and Peter A. Cerutti},
  journal={Biochemistry},
  year={1991},
  volume={30 38},
  pages={9305-13}
}
Oxidants are toxic, but at low doses they can stimulate rather than inhibit the growth of mammalian cells and play a role in the etiology of cancer and fibrosis. The effect of oxidants on cells is modulated by multiple interacting antioxidant defense systems. We have studied the individual roles and the interaction of Cu,Zn-superoxide dismutase (SOD) and catalase (CAT) in transfectants with human cDNAs of mouse epidermal cells JB6 clone 41. Since only moderate increases in these enzymes are… CONTINUE READING

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