The baculovirus cysteine protease has a cathepsin B-like S2-subsite specificity.

@article{Brmme1995TheBC,
  title={The baculovirus cysteine protease has a cathepsin B-like S2-subsite specificity.},
  author={Dieter Br{\"o}mme and Kuniaki Okamoto},
  journal={Biological chemistry Hoppe-Seyler},
  year={1995},
  volume={376 10},
  pages={611-5}
}
Autographa californica nuclear polyhedrosis virus (AcNPV) encodes a functional cysteine protease of the papain family which is expressed after infection in Spodoptera fruglperda Sf9 cells. The protease displays an inhibition profile typical for cysteine proteases and is highly active against synthetic peptide substrates. The pH optimum of the bell-shaped pH-activity curve is between 5.0 and 5.5. The best substrate tested is Z-Arg-Arg-MCA which is specific for cathepsin B. The specificity… CONTINUE READING

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