The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties.

@article{Ebensen2007TheBS,
  title={The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties.},
  author={Thomas Ebensen and Kai S Schulze and Peggy Riese and Claudia Link and Michael Morr and Carlos Alberto Guzm{\'a}n},
  journal={Vaccine},
  year={2007},
  volume={25 8},
  pages={
          1464-9
        }
}
The identification of new adjuvants is a critical need in vaccinology. In this work, it is demonstrated that bis-(3',5')-cyclic dimeric guanosine monophosphate (cdiGMP) exhibits potent adjuvant properties. Subcutaneous co-administration of cdiGMP with beta-galactosidase (beta-Gal) to mice resulted in the elicitation of significantly higher antigen-specific serum IgG titres than in animals receiving beta-Gal alone. Strong cellular immune responses, which were characterized by a balanced Th1/Th2… CONTINUE READING

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