The bacterial ribosome as a target for antibiotics

@article{Poehlsgaard2005TheBR,
  title={The bacterial ribosome as a target for antibiotics},
  author={Jacob Poehlsgaard and Stephen Douthwaite},
  journal={Nature Reviews Microbiology},
  year={2005},
  volume={3},
  pages={870-881}
}
Many clinically useful antibiotics exert their antimicrobial effects by blocking protein synthesis on the bacterial ribosome. The structure of the ribosome has recently been determined by X-ray crystallography, revealing the molecular details of the antibiotic-binding sites. The crystal data explain many earlier biochemical and genetic observations, including how drugs exercise their inhibitory effects, how some drugs in combination enhance or impede each other's binding, and how alterations to… Expand

Paper Mentions

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Nonconventional approaches to screening for ribosome inhibition and function of particular rRNA regions are described, including inhibitors against rRNA that may be designed according to nucleotide sequence and higher order structure. Expand
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TLDR
The structure of the intact Escherichia coli 70S ribosome in complex with hygromycin B is described and structural and biochemical results help to explain the unique mode of translation inhibition by hygroitcin B. Expand
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Findings reveal the functional importance of reversible intersubunit rotation to the translation mechanism and shed new light on the allosteric control of ribosome functions by small-molecule antibiotics. Expand
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TLDR
The data indicate that 4′-O-substituted aminoglycosides possess increased selectivity towards bacterial ribosomes and little activity for any of the human drug-binding pockets. Expand
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X-ray crystal structures of the Escherichia coli ribosome in complexes with clinically important antibiotics of four major classes are reported, arguing that the identity of nucleotides 752, 2609, and 2055 of 23S ribosomal RNA explain in part the spectrum and selectivity of antibiotic action. Expand
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