The bacterial ribosome as a target for antibiotics

  title={The bacterial ribosome as a target for antibiotics},
  author={J. Poehlsgaard and S. Douthwaite},
  journal={Nature Reviews Microbiology},
  • J. Poehlsgaard, S. Douthwaite
  • Published 2005
  • Biology, Medicine
  • Nature Reviews Microbiology
  • Many clinically useful antibiotics exert their antimicrobial effects by blocking protein synthesis on the bacterial ribosome. The structure of the ribosome has recently been determined by X-ray crystallography, revealing the molecular details of the antibiotic-binding sites. The crystal data explain many earlier biochemical and genetic observations, including how drugs exercise their inhibitory effects, how some drugs in combination enhance or impede each other's binding, and how alterations to… CONTINUE READING
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