The bacterial nucleoid: A highly organized and dynamic structure

  title={The bacterial nucleoid: A highly organized and dynamic structure},
  author={M. Thanbichler and S. C. Wang and L. Shapiro},
  journal={Journal of Cellular Biochemistry},
  • M. Thanbichler, S. C. Wang, L. Shapiro
  • Published 2005
  • Biology, Medicine
  • Journal of Cellular Biochemistry
  • Recent advances in bacterial cell biology have revealed unanticipated structural and functional complexity, reminiscent of eukaryotic cells. Particular progress has been made in understanding the structure, replication, and segregation of the bacterial chromosome. It emerged that multiple mechanisms cooperate to establish a dynamic assembly of supercoiled domains, which are stacked in consecutive order to adopt a defined higher‐level organization. The position of genetic loci on the chromosome… CONTINUE READING
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    Getting organized — how bacterial cells move proteins and DNA
    • 118
    Impact of Chromosomal Architecture on the Function and Evolution of Bacterial Genomes
    • 40
    • PDF
    Synchronization of chromosome dynamics and cell division in bacteria.
    • M. Thanbichler
    • Biology, Medicine
    • Cold Spring Harbor perspectives in biology
    • 2010
    • 60
    • PDF
    At the heart of the chromosome: SMC proteins in action
    • T. Hirano
    • Biology, Medicine
    • Nature Reviews Molecular Cell Biology
    • 2006
    • 518
    • PDF
    A MatP–divisome interaction coordinates chromosome segregation with cell division in E. coli
    • 151
    • PDF
    Physical descriptions of the bacterial nucleoid at large scales, and their biological implications.
    • 50
    • Highly Influenced
    • PDF
    Chromosome organizaton in simple and complex unicellular organisms.
    • 2
    • Highly Influenced
    • PDF


    The role of nucleoid‐associated proteins in the organization and compaction of bacterial chromatin
    • R. T. Dame
    • Biology, Medicine
    • Molecular microbiology
    • 2005
    • 334
    Spatial and temporal organization of replicating Escherichia coli chromosomes
    • 376
    • Highly Influential
    A moving DNA replication factory in Caulobacter crescentus
    • 125
    The role of co‐transcriptional translation and protein translocation (transertion) in bacterial chromosome segregation
    • 211
    Macrodomain organization of the Escherichia coli chromosome
    • 297
    • Highly Influential
    • PDF
    The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair.
    • T. Hirano
    • Biology, Medicine
    • Genes & development
    • 2002
    • 299
    • PDF
    MicroReview: Divided genomes: negotiating the cell cycle in prokaryotes with multiple chromosomes
    • 139
    Dynamic, mitotic-like behavior of a bacterial protein required for accurate chromosome partitioning.
    • 329
    • PDF