The bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironment.

@article{Dalmasso2014TheBG,
  title={The bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironment.},
  author={Guillaume Dalmasso and Antony Cougnoux and Julien Delmas and Arlette Darfeuille-Michaud and Richard Bonnet},
  journal={Gut microbes},
  year={2014},
  volume={5 5},
  pages={675-80}
}
The gut microbiota is suspected to promote colorectal cancer (CRC). Escherichia coli are more frequently found in CCR biopsies than in healthy mucosa; furthermore, the majority of mucosa-associated E. coli isolated from CCR harbors the pks genomic island (pks+ E. coli) that is responsible for the synthesis of colibactin, a genotoxic compound. We have recently reported that transient contact of a few malignant cells with colibactin-producing E. coli increases tumor growth in a xenograft mouse… CONTINUE READING