The bacterial gene lfpA influences the potent induction of calcitonin receptor and osteoclast-related genes in Burkholderia pseudomallei-induced TRAP-positive multinucleated giant cells.

@article{Boddey2007TheBG,
  title={The bacterial gene lfpA influences the potent induction of calcitonin receptor and osteoclast-related genes in Burkholderia pseudomallei-induced TRAP-positive multinucleated giant cells.},
  author={Justin A Boddey and Christopher J. Day and Cameron Flegg and Ricky L. Ulrich and Sebastien J. R. Stephens and Ifor R. Beacham and Nigel A. Morrison and Ian R A Peak},
  journal={Cellular microbiology},
  year={2007},
  volume={9 2},
  pages={514-31}
}
Burkholderia pseudomallei is a facultative intracellular pathogen and the causative agent of melioidosis, a spectrum of potentially fatal diseases endemic in Northern Australia and South-East Asia. We demonstrate that B. pseudomallei rapidly modifies infected macrophage-like cells in a manner analagous to osteoclastogenesis. These alterations include multinucleation and the expression by infected cells of mRNA for factors required for osteoclastogenesis: the chemokines monocyte chemotactic… CONTINUE READING
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Identification of a novel two-partner secretion system from Burkholderia pseudomallei

  • N. F. Brown, Logue, +4 authors I. R. Beacham
  • Mol Genet Genomics
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