The bacterial enzyme RppH triggers messenger RNA degradation by 5′ pyrophosphate removal

@article{Deana2008TheBE,
  title={The bacterial enzyme RppH triggers messenger RNA degradation by 5′ pyrophosphate removal},
  author={A. Deana and H. {\vC}ele{\vs}nik and J. Belasco},
  journal={Nature},
  year={2008},
  volume={451},
  pages={355-358}
}
  • A. Deana, H. Čelešnik, J. Belasco
  • Published 2008
  • Medicine, Biology
  • Nature
  • The long-standing assumption that messenger RNA (mRNA) degradation in Escherichia coli begins with endonucleolytic cleavage has been challenged by the recent discovery that RNA decay can be triggered by a prior non-nucleolytic event that marks transcripts for rapid turnover: the rate-determining conversion of the 5′ terminus from a triphosphate to a monophosphate. This modification creates better substrates for the endonuclease RNase E, whose cleavage activity at internal sites is greatly… CONTINUE READING
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