The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice: involvement of proinflammatory factors: nitric oxide and prostaglandins.

@article{Sayyah2003TheBE,
  title={The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice: involvement of proinflammatory factors: nitric oxide and prostaglandins.},
  author={Mohammad Sayyah and M Javad-Pour and Mahmood Ghazi-Khansari},
  journal={Neuroscience},
  year={2003},
  volume={122 4},
  pages={1073-80}
}
Central nervous system (CNS) inflammation in cases such as head trauma, infection and stroke has been associated with the occurrence of epileptic seizures. Microglia, the principal immune cells in the brain, readily become activated in response to injury, infection or inflammation. The bacterial endotoxin lipopolysaccharide (LPS) induces the activation of microglia and the production of proinflammatory factors including nitric oxide (NO) and prostaglandins (PGs). We examined the effect of LPS… CONTINUE READING

5 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Central nervous system ( CNS ) inflammation in cases such as head trauma , infection and stroke has been associated with the occurrence of epileptic seizures .
Central nervous system ( CNS ) inflammation in cases such as head trauma , infection and stroke has been associated with the occurrence of epileptic seizures .
The bacterial endotoxin lipopolysaccharide ( LPS ) induces the activation of microglia and the production of proinflammatory factors including nitric oxide ( NO ) and prostaglandins ( PGs ) .
The bacterial endotoxin lipopolysaccharide ( LPS ) induces the activation of microglia and the production of proinflammatory factors including nitric oxide ( NO ) and prostaglandins ( PGs ) .
The bacterial endotoxin lipopolysaccharide ( LPS ) induces the activation of microglia and the production of proinflammatory factors including nitric oxide ( NO ) and prostaglandins ( PGs ) .
The bacterial endotoxin lipopolysaccharide ( LPS ) induces the activation of microglia and the production of proinflammatory factors including nitric oxide ( NO ) and prostaglandins ( PGs ) .
The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice : involvement of proinflammatory factors : nitric oxide and prostaglandins .
The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice : involvement of proinflammatory factors : nitric oxide and prostaglandins .
Central nervous system ( CNS ) inflammation in cases such as head trauma , infection and stroke has been associated with the occurrence of epileptic seizures .
Central nervous system ( CNS ) inflammation in cases such as head trauma , infection and stroke has been associated with the occurrence of epileptic seizures .
Central nervous system ( CNS ) inflammation in cases such as head trauma , infection and stroke has been associated with the occurrence of epileptic seizures .
Central nervous system ( CNS ) inflammation in cases such as head trauma , infection and stroke has been associated with the occurrence of epileptic seizures .
The bacterial endotoxin lipopolysaccharide ( LPS ) induces the activation of microglia and the production of proinflammatory factors including nitric oxide ( NO ) and prostaglandins ( PGs ) .
The bacterial endotoxin lipopolysaccharide ( LPS ) induces the activation of microglia and the production of proinflammatory factors including nitric oxide ( NO ) and prostaglandins ( PGs ) .
The bacterial endotoxin lipopolysaccharide ( LPS ) induces the activation of microglia and the production of proinflammatory factors including nitric oxide ( NO ) and prostaglandins ( PGs ) .
The bacterial endotoxin lipopolysaccharide ( LPS ) induces the activation of microglia and the production of proinflammatory factors including nitric oxide ( NO ) and prostaglandins ( PGs ) .
The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice : involvement of proinflammatory factors : nitric oxide and prostaglandins .
The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice : involvement of proinflammatory factors : nitric oxide and prostaglandins .
The bacterial endotoxin lipopolysaccharide ( LPS ) induces the activation of microglia and the production of proinflammatory factors including nitric oxide ( NO ) and prostaglandins ( PGs ) .
The bacterial endotoxin lipopolysaccharide ( LPS ) induces the activation of microglia and the production of proinflammatory factors including nitric oxide ( NO ) and prostaglandins ( PGs ) .
The bacterial endotoxin lipopolysaccharide ( LPS ) induces the activation of microglia and the production of proinflammatory factors including nitric oxide ( NO ) and prostaglandins ( PGs ) .
The bacterial endotoxin lipopolysaccharide ( LPS ) induces the activation of microglia and the production of proinflammatory factors including nitric oxide ( NO ) and prostaglandins ( PGs ) .
The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice : involvement of proinflammatory factors : nitric oxide and prostaglandins .
The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice : involvement of proinflammatory factors : nitric oxide and prostaglandins .
Nervous system structureIs associated anatomic site ofEpilepsy
Central nervous system ( CNS ) inflammation in cases such as head trauma , infection and stroke has been associated with the occurrence of epileptic seizures .
Central nervous system ( CNS ) inflammation in cases such as head trauma , infection and stroke has been associated with the occurrence of epileptic seizures .
Pretreatment of mice with the NO synthase inhibitor , N(G)-nitro - L - arginine methyl ester or cyclooxygenase inhibitor , piroxicam or the opioid receptor antagonist , ( -)-naloxone completely reversed the proconvulsant effect of LPS .
Central nervous system ( CNS ) inflammation in cases such as head trauma , infection and stroke has been associated with the occurrence of epileptic seizures .
Central nervous system ( CNS ) inflammation in cases such as head trauma , infection and stroke has been associated with the occurrence of epileptic seizures .
Central nervous system ( CNS ) inflammation in cases such as head trauma , infection and stroke has been associated with the occurrence of epileptic seizures .
We examined the effect of LPS on seizure susceptibility of mice , by using the sensitive test , threshold of clonic seizures induced by i.v .
Central nervous system ( CNS ) inflammation in cases such as head trauma , infection and stroke has been associated with the occurrence of epileptic seizures .
Pretreatment of mice with the NO synthase inhibitor , N(G)-nitro - L - arginine methyl ester or cyclooxygenase inhibitor , piroxicam or the opioid receptor antagonist , ( -)-naloxone completely reversed the proconvulsant effect of LPS .
All Topics