The bacterial SRP receptor, SecA and the ribosome use overlapping binding sites on the SecY translocon.

@article{Kuhn2011TheBS,
  title={The bacterial SRP receptor, SecA and the ribosome use overlapping binding sites on the SecY translocon.},
  author={Patrick Kuhn and Benjamin Weiche and Lukas Sturm and Erik Sommer and Friedel Drepper and Bettina Warscheid and Victor Sourjik and Hans-Georg Koch},
  journal={Traffic},
  year={2011},
  volume={12 5},
  pages={563-78}
}
Signal recognition particle (SRP)-dependent protein targeting is a universally conserved process that delivers proteins to the bacterial cytoplasmic membrane or to the endoplasmic reticulum membrane in eukaryotes. Crucial during targeting is the transfer of the ribosome-nascent chain complex (RNC) from SRP to the Sec translocon. In eukaryotes, this step is co-ordinated by the SRβ subunit of the SRP receptor (SR), which probably senses a vacant translocon by direct interaction with the… CONTINUE READING

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