The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities.

@article{Yun2007TheBP,
  title={The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities.},
  author={Chul-Ho Yun and K Kim and Dong-Hyun Kim and Heung-Chae Jung and J Pan},
  journal={Trends in biotechnology},
  year={2007},
  volume={25 7},
  pages={289-98}
}
The use of cytochrome P450 (P450 or CYP) enzymes as biocatalysts for the production of fine chemicals, including pharmaceuticals, has been of increasing interest, primarily owing to their catalytic diversity and broad substrate range. CYP102A1 (P450 BM3) from Bacillus megaterium integrates an entire monooxygenase system into one polypeptide and represents an appropriate prokaryotic model for industrial applications of mammalian P450 activities. CYP102A1 not only exhibits the highest catalytic… CONTINUE READING