The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases.

@article{Konz1997TheBB,
  title={The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases.},
  author={Dirk D. Konz and A Klens and Kurt Sch{\"o}rgendorfer and Mohamed A. Marahiel},
  journal={Chemistry & biology},
  year={1997},
  volume={4 12},
  pages={927-37}
}
BACKGROUND The branched cyclic dodecylpeptide antibiotic bacitracin, produced by special strains of Bacillus, is synthesized nonribosomally by a large multienzyme complex composed of the three bacitracin synthetases BA1, BA2 and BA3. These enzymes activate and incorporate the constituent amino acids of bacitracin by a thiotemplate mechanism in a pathway driven by a protein template. The biochemical features of these enzymes have been studied intensively but little is known about the molecular… CONTINUE READING

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