The baboon model of pertussis: effective use and lessons for pertussis vaccines

@article{Warfel2014TheBM,
  title={The baboon model of pertussis: effective use and lessons for pertussis vaccines},
  author={J. Warfel and T. Merkel},
  journal={Expert Review of Vaccines},
  year={2014},
  volume={13},
  pages={1241 - 1252}
}
  • J. Warfel, T. Merkel
  • Published 2014
  • Medicine
  • Expert Review of Vaccines
  • The USA is experiencing a pertussis resurgence that resulted in a 60-year high of 48,000 cases in 2012. Our ability to counteract this resurgence is hampered by the fact that pertussis pathogenesis and immunity to pertussis infection are not well studied. Studies in humans are difficult due to the low frequency of pertussis in the population, the cyclical nature of incidence and the sporadic geographic distribution of cases. While existing animal models reproduce many aspects of pertussis, none… CONTINUE READING

    Topics from this paper.

    Contribution of pertussis toxin to the pathogenesis of pertussis disease.
    • 34
    • PDF
    Pertussis vaccines
    • 26
    Pertussis vaccines and protective immunity.
    • 17

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 103 REFERENCES
    A search for serologic correlates of immunity to Bordetella pertussis cough illnesses.
    • 394
    Nonhuman Primate Model of Pertussis
    • 94
    • PDF
    Bordetella pertussis pathogenesis: current and future challenges
    • 179
    Immunity to the respiratory pathogen Bordetella pertussis
    • 178
    • PDF