The bZIP Transcription Factor Rca1p Is a Central Regulator of a Novel CO2 Sensing Pathway in Yeast

@inproceedings{Cottier2012TheBT,
  title={The bZIP Transcription Factor Rca1p Is a Central Regulator of a Novel CO2 Sensing Pathway in Yeast},
  author={Fabien Cottier and Martine Pinçon Raymond and Oliver Kurzai and Marianne Bolstad and Worraanong Leewattanapasuk and Claudia Jim{\'e}nez-L{\'o}pez and Michael C Lorenz and Dominique Sanglard and Libu{\vs}e V{\'a}chov{\'a} and Norman Pavelka and Zdena Palkov{\'a} and Fritz A. M{\"u}hlschlegel},
  booktitle={PLoS pathogens},
  year={2012}
}
Like many organisms the fungal pathogen Candida albicans senses changes in the environmental CO(2) concentration. This response involves two major proteins: adenylyl cyclase and carbonic anhydrase (CA). Here, we demonstrate that CA expression is tightly controlled by the availability of CO(2) and identify the bZIP transcription factor Rca1p as the first CO(2) regulator of CA expression in yeast. We show that Rca1p upregulates CA expression during contact with mammalian phagocytes and… CONTINUE READING

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