The b 2 a Subunit Is a Molecular Groom for the Ca 2 1 Channel Inactivation

  title={The b 2 a Subunit Is a Molecular Groom for the Ca 2 1 Channel Inactivation},
  author={Gate S. Restituito and Thierry Cens and Christian Barr{\`e}re and Sandrine Geib and Simon Galas and Michel de Waard and Pierre Charnet},
Ca channel inactivation is a key element in controlling the level of Ca entry through voltage-gated Ca channels. Interaction between the pore-forming a1 subunit and the auxiliary b subunit is known to be a strong modulator of voltage-dependent inactivation. Here, we demonstrate that an N-terminal membrane anchoring site (MAS) of the b2a subunit strongly reduces a1A (CaV2.1) Ca 21 channel inactivation. This effect can be mimicked by the addition of a transmembrane segment to the N terminus of… CONTINUE READING


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Recent advances in the molecular understanding of voltage-gated Ca 21 channels

  • A Randall, CD Benam
  • Mol Cell Neurosci
  • 1999
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