The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose.

@article{Treede2003TheAR,
  title={The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose.},
  author={Irina Treede and Lene Jakobsen and Finn Kirpekar and Birte Vester and Gabriele Weitnauer and Andreas Bechthold and S. Douthwaite},
  journal={Molecular microbiology},
  year={2003},
  volume={49 2},
  pages={309-18}
}
Avilamycin is an orthosomycin antibiotic that has shown considerable potential for clinical use, although it is presently used as a growth promoter in animal feed. Avilamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. The ribosomes of the producer strain, Streptomyces viridochromogenes Tü57, are protected from the drug by the action of three resistance factors located in the avilamycin biosynthetic gene cluster. Two of the resistance factors, aviRa and aviRb… CONTINUE READING
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