The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration.

@article{Katzman1989TheAR,
  title={The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration.},
  author={Martin Katzman and Richard A. Katz and Anna Marie Ann Skalka and Jonathan Leis},
  journal={Journal of virology},
  year={1989},
  volume={63 12},
  pages={5319-27}
}
The purified integration protein (IN) of avian myeloblastosis virus is shown to nick double-stranded oligodeoxynucleotide substrates that mimic the ends of the linear form of viral DNA. In the presence of Mg2+, nicks are created 2 nucleotides from the 3' OH ends of both the U5 plus strand and the U3 minus strand. Similar cleavage is observed in the presence of Mn2+ but only when the extent of the reaction is limited. Neither the complementary strands nor sequences representing the termini of… CONTINUE READING
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