The avian IGF type 1 receptor: cDNA analysis and in situ hybridization reveal conserved sequence elements and expression patterns relevant for the development of the nervous system.

@article{Holzenberger1996TheAI,
  title={The avian IGF type 1 receptor: cDNA analysis and in situ hybridization reveal conserved sequence elements and expression patterns relevant for the development of the nervous system.},
  author={Martin Holzenberger and F Lapointe and Michel Leibovici and Christiane Ayer-Le Li{\`e}vre},
  journal={Brain research. Developmental brain research},
  year={1996},
  volume={97 1},
  pages={76-87}
}
Insulin-like growth factor type 1 receptor (IGF-1R) is a tyrosine kinase with a key role in development. The primary structure of IGF-1R is known for mammalian species, but not for birds. The avian embryo, however, provides an ideal system for the experimental study of neurogenesis. We therefore cloned the complete coding sequence of the chicken IGF-1R from a cDNA library and analyzed its embryonic expression by Northern blot and in situ hybridization. The deduced chicken IGF-1R precursor of… CONTINUE READING

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