The availability of carfecillin and its phenol moiety in rat and dog.

@article{Humphrey1980TheAO,
  title={The availability of carfecillin and its phenol moiety in rat and dog.},
  author={Michael John Sandwich Humphrey and Colin Filer and David J. Jeffery and Paul C. Langley and G. A. Wadds},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1980},
  volume={10 10},
  pages={
          771-8
        }
}
1. Studies have shown that hydrolysis of carfecillin to carbenicillin and phenol in vitro occurs in blood, liver and gut tissues of rat and dog. Extremely rapid hydrolysis was observed in the blood and liver of the rat. 2. Absorption studies in intestinally-perfused rats showed that following administration of either [14C]phenol or [phenol-14C]carfecillin, the half-life values of radioactivity in the intestinal lumen were 6 min and 47 min respectively. 3. Following oral administration of phenol… CONTINUE READING
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